منابع مشابه
Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone
BACKGROUND Use of azathioprine (AZA) for inflammatory bowel disease is limited by side effects or poor efficacy. Combining low-dose azathioprine with allopurinol (LDAA) bypasses side effects, improves efficacy, and may be appropriate as first-line therapy. We test the hypothesis that standard-dose azathioprine (AZA) and LDAA treatments work by similar mechanisms, using incorporation of the meta...
متن کاملHistological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction
The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a useful tool. The measurement has been used during the treatment of inflammatory bowel diseases and, less commonly, in autoimmune hepatitis. Ma...
متن کاملEffect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.
BACKGROUND & AIMS Many IBD patients not responding to azathioprine (AZA) or 6-mercaptopurine (6-MP) preferentially metabolize 6-MP to 6-methylmercaptopurine (6-MMP). We describe the use of allopurinol in AZA/6-MP nonresponders to deliberately shunt metabolism of 6-MP toward 6-thioguanine (6-TGN) and improve clinical responses. METHODS Twenty outpatients who were AZA/6-MP nonresponders and had...
متن کاملLong term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease.
BACKGROUND AND AIMS We previously reported that IBD patients who are non-responders to thiopurines with preferential shunting of metabolites to hepatotoxic 6-methylmercaptopurine ribonucleotides compared to 6-thioguanine nucleotides can reverse the ratio of 6-MMP/6-TGN and respond to thiopurines with the addition of allopurinol. The objective of this study is to report long term efficacy and sa...
متن کاملTreatment of gout with allopurinol and sulphinpyrazone in combination and with allopurinol alone.
Successful long-term management of primary gout in the presence of normal renal function may be achieved in most instances by agents which diminish tubular reabsorption of urates, thus permitting increased urinary urate excretion. In recent years the two most widely used uricosuric agents have been probenecid and sulphinpyrazone. The easiest longterm control of gout with the fewest untoward sid...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2017
ISSN: 1078-0998
DOI: 10.1097/mib.0000000000001131